目的：研究分析妊娠伴发甲状腺功能减退症对妊娠结局的影响，以供临床研究与实践提供可参考依据。方法病例资料均来源于2011年12月～2013年12月我院收治的45例妊娠伴发甲状腺功能减退症的孕妇，将其设为实验组，选取同期在我院分娩的正常孕妇45例设为对照组，监测两组受试人员在不同时期促甲状腺激素水平（TSH）与妊娠结局，并运用统计学比较分析。结果实验组孕产妇在孕早期、孕中期、孕晚期及产后等不同时期的TSH浓度分别为（2.9±0.2）mU/L、（6.4±0.1）mU/L、（8.1±0.2）mU/L、（7.6±0.6）mU/L与对照组的（1.2±0.1）mU/L、（2.3±0.3）mU/L、（2.9±0.4）mU/L、（1.4±0.1）mU/L相比均明显更高，差异具有统计学意义（P＜0.05）；实验组孕产妇的产后出血率为11.1%与对照组的4.4%相比无明显差异（P＞0.05），而其剖宫产、早产、贫血、自发性流产、妊高症、新生儿窒息等发生率分别为40.0%、22.2%、20.0%、24.4%、26.7%、15.6%与对照组的17.8%、2.2%、0、4.4%、6.7%、4.4%、0相比均显著更高（P＜0.05），新生儿体重为（3428.8±258.7）g，则显著低于对照组的（3679.9±276.6）g，差异有统计学意义（P＜0.05）。结论妊娠伴发甲状腺功能减退症对妊娠结局及胎儿有不良影响，临床应在各阶段加强对妊娠甲状腺功能减退的筛查，必要时采取针对性治疗，以降低不良妊娠结局的发生。%Objective To study and analyze the effect of pregnancy accompanied by hypothyroidism on pregnancy outcome to provide reference for clinical research and practice. Methods Data of 45 pregnant women with hypothyroidism who were admitted to our hospital from December 2011 to December 2013 the clinical data were derived from December 2011 to December 2013 were selected and they were set as the experimental group. 45 healthy pregnant women during the same period were selected as the control group. Thyroid stimulating hormone (TSH) levels and pregnancy outcomes in different stages of subjects in two groups were monitored and received comparative analysis according to statistics. Results TSH concentrations of early pregnancy, mid-pregnancy, late pregnancy, after delivery and other different stages of pregnant women in the experimental group were (2.9±0.2) mU/L, (6.4±0.1) mU/L, (8.1±0.2) mU/L and (7.6±0.6) mU/L respectively, all significantly higher than those of the control group (1.2±0.1)mU/L, (2.3±0.3) mU/L, (2.9±0.4) mU/L and (1.4±0.1) mU/L. The difference was significant by statistical analysis (P<0.05). Postpartum hemorrhage rates of the experimental group and the control group were 11.1% and 4.4% respectively. When two groups were compared, there was no significant difference (P > 0.05). Incidences of cesarean section, premature birth, anemia, spontaneous abortion, pregnancy induced hypertension and neonatal asphyxia of the experimental group were 40.0%, 22.2%, 20.0%, 22.2%, 26.7% and15.6% respectively, all significantly higher than those of the control group 17.8%, 2.2%, 4.4%, 6.7%, 4.4%, 0 (P<0.05). Neonatal weight of the observation group was (3428.8+258.7) g, significantly lower than that of the control group (3679.9 ± 276.6) g. The difference was statistically significant (P<0.05). Conclusion Pregnancy accompanied by hypothyroidism has bad effect on pregnancy outcomes and fetus. In clinic, screening for pregnancy with hypothyroidism in different stages should be strengthened and targeted treatment should be adopted if necessary to reduce incidence of poor pregnancy outcomes.
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