三苯氧胺对乳腺癌围绝经期患者性激素水平的影响

摘要

Objective: To explore the effect of Tamoxifen (TAM) on sex hormone level of breast cancer patients at perimenopausal period. Methods: 200 patients with breast cancer at perimenopausal period were selected and they were separated into taking TAM group and not taking TAM group. 60 healthy women at perimenopausal period in the out-patient department were selected as control group. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) of the patients were assayed using full-automation chemiluminescence method. Results: There was no statistical significance in FSH, LH, E2 between the not taking TMA group and control group (P>0.05). The levels of FSH and LH in the taking TMA group were obviously lower than the control group and not taking TMA group, the level of E2 in the taking TMA group was slightly higher than the control group and not taking TMA group, and there were statistical significance ditperences (P<0.01). Conclusion: Taking TMA can obviously affect sex hormone level of breast cancer patients at perimenopausal period, which should be aroused attention in clinic, so that breast cancer patients at perimenopausal period will get better and more timely treatment than before and their survival rate will be further improved.%目的:探讨三苯氧胺(TAM)对乳腺癌围绝经期患者性激素水平的影响.方法:选取200例围绝经期乳腺癌患者,分为服用及未服用TAM治疗组各100例,60例门诊健康体检围绝经期妇女为对照组,全都采用全自动化学发光法测定血清卵泡刺激素(FSH)、促黄体生成激素(LH)、雌二醇(E2)水平.结果:未服用TAM组与对照组FSH、LH、E2水平差异均无统计学意义(P＞0.05);服用TAM组血清FSH、LH水平明显低于对照组和未服用TAM组,而E2含量却略高于对照组和未服用TAM组,差异有高度统计学意义(P＜0.01).结论:服用TAM会明显影响乳腺癌围绝经期患者的性激素水平,临床应予以重视,以便让围绝经期乳腺癌患者得到更好、更及时的治疗,进一步提高其生存率.