Objective: To evaluate the condition of Cefdinir in the treatment of mild and moderate bacterial infections. Methods: Adopt randomized controlled clinial study of Cefdinir and Cefteram were given the treatment with dose of 100-200 mg, tid for 7-14 d. According to the symptom, physical sign, and the results of examination, the clinical efficacy of Cefdinir was judged. Through the bacteriological isolation and culture, evaluated the bacterial eradication rates. And drug susceptibility were determined with drug sensitive slips method. Results: The cure rates of Cefdinir and Cefteram were 78.1% and 77.3%, and the effective rates were 97.1% and 95.5% respectively. The bacterial eradication rates of the two groups were 97.7%, 92.2% respectively. The susceptibility rates were 91.5% and 93.8%. Adverse events rate were 6.3% and 8.8% respectively in the two groups. And there were no statistical significant difference (P>0.05). Conclusion: Cefdinir is an effective and well tolerated antibacterial agent for the treatment of mild and moderate bacterial infections.%目的:评价头孢地尼治疗轻、中度细菌感染的疗效以及体外抗菌活性情况.方法:选择轻中度细菌感染的患者,分为头孢地尼组和头孢特仑酯组(对照组)进行随机对照研究.两组患者均给予100～200 mg,tid,疗程7～14 d 治疗.根据患者症状、体征、实验室及病原学检查结果,判断头孢地尼的临床疗效.同时在治疗前后做细菌学分离培养、进行细菌学评价,应用纸片法药敏试验测定药物敏感性.结果:在治疗轻、中度细菌感染方面,头孢地尼组治愈率分别为78.1%、76.4%,总有效率分别为97.1%、95.5%.两组的细菌清除率为97.7%和92.2%,药物敏感率为91.5%、93.8%,不良反应发生率为6.3%、8.8%,差异均无统计学意义(P＞0.05).但头孢地尼组药物敏感率均高于阿莫西林组及环丙沙星组(P＜0.05).结论:头孢地尼对于治疗轻中度细菌感染安全高效.
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