Objective: To evaluate relationship between overuse of antibiotics and bacterial resistance, to provide a reasonable basis for the clinical use of antibiotics. Methods: From January 2005 to December 2010, continuous observation of bacterial susceptibility testing during the G" infections were given in our institute. Culture for pathogens isolated culture according to conventional methods were identified to species after pure germ, 337 pathogenic bacteria were cultured (except fungi). Results: The use of third-generation cephalosporins in 305 cases of patients with bacterial infection was first (41.39%), followed by qumolones (29.80%); five bacteria were the highest resistance to cefuroxime. Specimens from 305 patients out of 337 strains were isolated pathogens cultured germ, followed by 183 strains of Pseudomonas aeruginosa, 70 strains of Klebsiella pneumoniae, 46 strains of Escherichia coli, 22 strains of Enterbacter cloacae, Slaphylococcus aureus was 16 strains. Conclusion: The clinical unreasonable use of antibiotics can make bacteria resistant, G" bacteria to first and second generation cephalosporins, higher resistance to penicillin, while the third generation cephalosporins. Quinolones%目的:探讨过量使用抗生素与细菌耐药性的关系,为临床上合理使用抗生素提供依据.方法:2005年1月~2010年12月,对我所G-感染菌药敏试验进行连续观察.病原菌培养按常规方法培养分离,获纯菌后鉴定到种,共培养出337株致病菌(真菌除外).结果:选取的305例细菌感染患者使用第三代头孢菌素居第一位(41.39%),其次为喹诺酮类(29.80%);5种细菌对头孢呋肟的耐药性最高.从305例患者标本中共分离培养出337株病原菌,依次为铜绿假单胞菌183株、肺炎克雷伯菌70株、大肠埃希菌46株、阴沟杆菌22株、金黄色葡萄球菌16株.结论:临床过量应用抗生素不合理可使细菌产生耐药性,G-菌对头孢一、二代及青霉素有较高耐药性,而对三代头孢菌素、喹诺酮类耐药性逐渐增加.
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