目的:观察乌司他丁在急性肺损伤/急性呼吸窘迫综合征中的治疗效果.方法:将52例急性肺损伤/急性呼吸窘迫综合征患者随机分为对照组(26例)和治疗组(26例),对照组予常规综合治疗,治疗组在此基础上加用乌司他丁辅助治疗.比较两组呼吸、心率、平均动脉压、血气分析结果及死亡率.结果:治疗组治疗后呼吸频率、心率、氧分压、动脉血氧饱和度分别为(18.9±3.6)次/min、(78.3±9.5)次/min、(98.4±10.5)mm Hg、(96.9±3.1)%,效果优于对照组的(21.3±3.2)次/min、(86.5±10.7)次/min、(75.9±8.7)mm Hg、(79.2±5.9)%,差异有统计学意义(P<0.05);对照组死亡率为26.9%(7/26),治疗组死亡率为11.5%(3/26),两组比较差异有统计学意义(P<0.05).结论:乌司他丁辅助治疗急性肺损伤/急性呼吸窘迫综合征疗效确切,可推广应用.%Objective: To observe the efficacy of Ulinastain to the acute lunginjury/acute respiratory distress syndrome. Methods: 52 cases of patients with acute lunginjury/acute respiratory distress syndrome were randomly divided into control group (26 cases) and treatment group (26 cases). The control group was treated by routine combined therapy, and the treat -ment group was treated by Ulinastain for injection based on the routine combined therapy. And then the respiratory rate, heart rate, mean arterial pressure and blood-gas analysis, mortality rate of the two groups were compared. Results: The respiratory rate, heart rate, PaO2, SaO2 of the treatment group was (18.9±3.6) times/min, (78.3±9.5) times/min, (98.4±10.5) mm Hg, (96.9±3.1)% respectively, all were superior to the (21.3±3.2) times /min, (86.5±10.7) times /min, (75.9±8.7) mm Hg, (79.2± 5.9)% of the control group, the differences were significant (P<0.05); the mortality rate of the control group was 26.9% (7/ 26), which was higher than the 11.5% (3/26) of the treatment group, the difference was statistically significant (P<0.05). Conclusion: The efficacy of Ulinastain to the acute lunginjury/acute respiratory distress syndrome is exact, and it is worth of popularizing.
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