Objective: To compare the efficacy of intranasal Butorphanol with different doses for prevention of Propofol -induced pain. Methods: 90 patients of ASA I - II undergoing selective craniotomy were divided into three groups, group I received saline 0.3 ml, group II received Butorphanol 2 mg, and group Ⅲ received Butorphanol 3 mg. The intranasal medicine was giving 15 minutes before anesthesia induction. All patients received one-fourth of the total dose of Propofol (2 mg/kg) in the speed of 5 mg/s. Assessment of pain with Propofol was done by using a four-point scale, 0=no pain, 1 = mild pain, 2=moderate pain and 3=severe pain at the time of Propofol injection. Results: In group I , 70% patients had pain during Propofol injection, and in group Ⅱ and group Ⅲ were 53.3% and 26.7%, respectively. The patients with injection pain in group Ⅲ were significantly less than group I (P<0.05). Conclusion: The application of intranasal Butorphanol 3 mg 15 min before anesthesia can effectively attenuate the pain associated with Propofol.%目的:比较经鼻给予不同剂量布托啡诺对丙泊酚注射痛的影响.方法:采用随机、双盲、对照研究.将ASAⅠ～Ⅱ级择期行开颅手术的90例患者随机分为三组,每组各30例.所有患者麻醉诱导前15 min经鼻给药.Ⅰ组给予生理盐水0.3 ml,Ⅱ组给予布托啡诺2 mg,Ⅲ组给予布托啡诺3 mg.以5 mg/s速度给予患者1/4总剂量的丙泊酚(2 mg/kg).静脉注射丙泊酚时采用4点法对疼痛评分,0=无痛,1=轻度疼痛,2=中度疼痛,3=严重疼痛.结果:Ⅰ组有70%患者诉疼痛;Ⅱ组和Ⅲ组分别为53.3%和26.7%.Ⅲ组跟Ⅰ组比较,疼痛发生率明显降低(P<0.05).结论:麻醉前15 min经鼻给予布托啡诺3 mg能预防丙泊酚注射痛.
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