短期胰岛素强化治疗新诊断2型糖尿病患者84例疗效观察

摘要

目的:观察短期胰岛素强化治疗新诊断2型糖尿病患者的疗效.方法:对84例新诊断2型糖尿病患者采用3餐前30 min及睡前皮下注射胰岛素强化治疗,2～4周使血糖得到有效控制,然后分别行饮食、运动和药物治疗(降糖药物或降糖药物联合胰岛素),随防6个月,比较治疗前、后患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、餐后2h胰岛素(2 h INS)、糖化血红蛋白(HbA1c)、β细胞指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、三酰甘油(TG)、总胆固醇(TC)、体重指数(BMI)指标的变化.结果:治疗后FBG、2 h PG、HOMA-IR及HbA1c水平较治疗前显著下降(P<0.01),2 h INS、HOMA-β水平较治疗前显著上升(P<0.01),FINS、BMI、TG、TC水平与治疗前比较,差异无统计学意义治疗(P>0.05).结论:短期胰岛素强化治疗能改善新诊断2型糖尿病患者胰岛素分泌功能和胰岛素的敏感性,有效控制血糖,值得临床推广.%Objective: To observe the effect of short-term intensive insulin therapy in newly diagnosed type 2 diabetes patients. Methods: 84 patients who were newly diagnosed with type 2 diabetes were given subcutaneous insulin therapy in 30 min before three meals and before sleep. Blood glucose was effectively controlled in 2 to 4 weeks, then the patients were given diet, exercise and medications therapy (hypoglycemic drugs or descending sugar, insulin drug combination). All patients were followed up 6 months, and the FBG, 2 h PG, FINS, 2 h INS, HbA1c, HOMA-3, HOMA-IR, TG, TC, BMI were compared before treatment and after treatment. Results: Six months after treatment, the FBG, 2 h PG, HOMA-IR and HbA1c decreased significantly (P<0.01), 2 h INS, HOMA-3 increased significantly (P<0.01), FINS, BMI, TG, TC had no4 significant change (P<0.05). Conclusion: Short-term intensive insulin therapy can improve insulin secretion and insulin sensitivity in patients newly diagnosed type 2 diabetes, control blood sugar effectively, and it is worthy of promotion.