糖尿病患者检测β2-微球蛋白的临床意义

摘要

目的:探讨血、尿β2-微球蛋白(β2-MG)对糖尿病患者的临床意义.方法:用放射免疫方法测定糖尿病患者血、尿β2-MG的水平.结果:糖尿病患者血、尿β2-MG含量明显高于健康人员(P<0.01),且随着病程的延长,血、尿β2-MG的含量明显增加;血、尿β2-MG的含量在非胰岛素依赖性糖尿病(NIDDM)和胰岛素依赖性糖尿病(IDDM)患者之间比较,差异无统计学意义(P>0.05).结论:测定糖尿病患者血、尿β2-MG对早期发现、预防和治疗糖尿病肾病有重要的临床意义.%Objective: To study the clinical significance to detect the blood and urine β2-microglobulin protein (β2-MG)of diabetic patients.Methods: lhe levels of blood and urine β2-MG of diabetic patients were measured by radioimmunoassay.Results: The levels of blood and urine β2-MG of diabetic patients were significantly higher than health people in the control group (P＜0.01), and the levels of blood and urine β2-MG were significantly increased with the duration of the extension.There was no statistically significant difference between non-insulin-dependent diabetes mellitus (NIDDM) and insulin-dependent diabetes mellitus (IDDM) patients in levels of blood and urine β2-MG (P＞0.05).Conclusion: It has an important clinical significance of diabetic patients to determine the levels of blood and urine β2-MG on the early detection to prevent and treat the diabetic nephropathy.