米非司酮联合水囊终止瘢痕子宫中期妊娠临床观察

摘要

目的:观察瘢痕子宫中期妊娠引产中应用米非司酮联合水囊的安全性与有效性.方法:选择妊娠18～24周有剖宫产史的孕妇60例,B超提示子宫瘢痕愈合良好,将60例孕妇随机分为观察组和对照组,每组各30例.其中,观察组30例患者采用米非司酮联合自制水囊引产方法;对照组采用自制水囊引产方法.结果:观察组置入水囊到宫缩发动时间(17.05±6.61)h、总产程(13.67±4.52)h与对照组[(25.05±7.30)h、(18.75±5.23)h]比较,差异有高度统计学意义(P<0.01);观察组胎盘胎膜残留率(16.67%)、产后出血量(62.38±32.04)ml与对照组[(26.67%)、(75.12±33.25)ml]比较,差异无统计学意义(P>0.015);两组均无子宫破裂及软产道裂伤.结论:米非司酮联合自制水囊终止瘢痕子宫中期妊娠是安全有效的.%Objective: To investigate the safety and efficacy of the method of Mifepristone and homemade-water bag for mid-trimester termination in women (18-24 weeks of pregnancy) with previous cesarean section. Methods: 60 eases of pregnant women with history of cesarean section, B Super Tips uterine sear healed well, 60 pregnant women were randomly divided into the observation groups and the control group, 30 patients in each group. The observation group's 30 patients were made use of Mifepristone for labor induction water bag; 30 cases of control group with homemade water bag induction method. Results: There was significant difference (P＜0.01) between observation group launched into bladders to the contraction time (17.05±6.61)h, total process (13.67±4.52)h and the control group [(25.05±7.30)h, (18.75±5.23)h]; observed residual rate of placental membranes (16.67％), postpartum hemorrhage (62.38±32.04)ml placental membranes and the control group [(26.67％), (75.12±33.25)ml] had no significant difference (P＞0.05); two groups had no uterine rupture and laceration of soft birth canal. Conclusion: Mifepristone and homemade-water bag uterine scar pregnancy termination is effective and safe.