N-乙酰天门冬氨酸测定在急性脑梗死的临床应用

摘要

Objective: To compare the measured values of N-acetylaspartate (NAA) before and after the treatment of acute cerebral infarction by magnetic resonance spectrum (MRS) analysis technology.Methods: 90 cases of patients with acute cerebral infarction before and after treatment inspected by MRS, measured values of NAA in infarction location before treatment, compared with the symmetric health part before treatment and the infarction location after treatment and analyses its changing characteristics, and neurologic deficits scores (NIHSS) was measured before treament and 2 weeks after treatment.Results: The values of NAA in infarction location before treatment was lower than in the symmetric health part before treatment (P＜0.01).NIHSS had no correlation with NAA(r=0.1221, P＞0.05); the values of NIHSS after treatment decreased obviously than before treatment (P＜0.001), but the values of NAA in infarction location after treatment compared with before treatment had no statistically significant (P＞0.05).Conclusion: Using magnetic resonance spectrum (MRS) analysis techniques can be non-invasive detection of the dynamic changes of NAA of acute cerebral infarction, which can understand the organization metabolism of cerebral location infarction, provide more clinical evidence for early diagnosis, treatment and prognosis of the disease.%目的:应用磁共振波谱(MRS)分析技术,对急性脑梗死治疗前后N-乙酰天门冬氨酸(N-acetylaspanate,NAA)的测定值进行比较.方法:对90例急性脑梗死患者治疗前后进行MRS检查,测定治疗前梗死病灶部位(患侧1)的NAA值,与治疗前对称健侧部位(健侧)及治疗后梗死病灶部位(患侧2)的NAA值进行对比并分析其变化特点,于治疗前及治疗后2周进行神经功能缺损评分(NIHSS)测定.结果:治疗前梗死病灶部位(患侧1)的NAA值低于治疗前健侧部位(健侧)的NAA值,差异具有统计学意义(P<0.01);神经功能缺损评分(NIHSS)与NAA无相关性,治疗后与治疗前比较NIHSS值明显下降(P<0.001),但治疗后梗死病灶部位(患侧2)的NAA值与治疗前梗死病灶部位(患侧1)的NAA值比较,差异无统计学意义(P＞0.05).结论:利用磁共振波谱(MRS)分析技术可无创检测急性脑梗死的N-乙酰天门冬氨酸的动态变化,从而可以了解脑梗死病灶部位的组织代谢动态变化.为疾病的早期诊断、治疗及判断预后提供更多临床依据.