金纳多治疗短暂性脑缺血发作58例临床观察

摘要

Objective: To explore the therapeutic effects and hemorheology of Ginkgo biloba extract on transient ischemic attack. Methods: 58 patients with transient ischemic attack were randomly divided into treatment group and control group. The treatment group was treated with Cinkgo biloba extract intravenously, and the control group was treated with Dextran, Oryzanol and Vitamin etc.. Results: The effective rate of the treatment group was significantly higher than that of the control group (93.3％ vs 64.3％,ρ＜0.01). The whole blood viscosity, platelet clinging rate and fibrinogen in the treatment group decreased (ρ＜0.01), plasma viscosity also decreased, but all indexes had no difference in the control group after treatment, there were significant difference in indexes above between two groups (ρ＜0.05). Conclusion: Ginkgo biloba extract can improve the clinical symptoms of the patients with transient ischemic attack and decrease the blood viscosity, and the control group can alleviate the clinical symptoms, but there is no difference in the blood viscosity. Ginkgo biloba extract has good therapeutic effects on transient ischemic attack.%目的:探讨金纳多(银杏叶提取物)对短暂性脑缺血发作(transient ischemic attack,TIA)患者的疗效、血液流变学的影响.方法:将58例TIA患者随机分为两组,治疗组采用金纳多静脉点滴,对照组给予低分子右旋糖酐、谷维素或维生素等,对两组患者的疗效、血液流变学进行比较.结果:治疗组有效率为93.3%,明显高于对照组的64.3%,两组比较差异有高度统计学意义(P<0.01);治疗后治疗组全血黏度、血小板黏附率、纤维蛋白原明显降低(P<0.01),血浆黏度也降低(P<0.05),对照组各项指标均无明显改变;两组治疗后以上各指标相比较,差异有统计学意义(P<0.05).结论:金纳多能显著改善TIA患者的临床症状,降低血液黏度;而对照组能够缓解临床症状,对血液黏度无明显改善.金纳多治疗TIA效果确切,值得临床推广.