Objective To investigate the effect of Dexmedetomidine prophylactic splenectomy cardiac devascLilarization operation in patients with postoperative shivering in the occurrence and maintenance of hemodynamic stability. Methods 120 cases with hepatitis B, liver cirrhosis in operation of splenectomy cardiac devascularization were randomly divided into dexmedetomidine (D) group and normal saline (S) group with 60 cases in each group, the two groups were treated with combined intravenous anesthesia. Dexmedetomidine diluents were added to group D with 1 μg/kg and pumped in 15 minutes, the maintenance dose was 0.2-0.4 μg/(kg·h). 15 mL normal saline was infused in S group and routine intravenous inhalation anesthesia intraoperative was maintained. Postoperative shivering case, degree and hemodynamic stability were ob served in the two groups. Results The case of postoperative shivering was found better than that in group S and the degree was found lower than that in group S, the differences were all statistically significant (all P < 0.01). Hemodynamic stability in group D was found better than that in group S (P < 0.05). Conclusion Dexmedetomidine can effectively reduce the postoperative shivering incidence of cardiac devascularization splenectomy operation and stabilize the hemodynamic changes.%目的 探讨右美托咪定预防脾切除贲门血管离断术患者术后寒战发生情况及维持血流动力学的稳定性.方法 选择乙肝、肝硬化行脾切除贲门血管离断术患者共120例,随机分为右美托咪定(D)组和生理盐水(S)组,每组各60例,两组均采用静吸复合麻醉.D组加用1 μg/kg的右旋美托咪定稀释液,15 min泵入,术中维持剂量0.2～0.4 μg/(kg·h).S组静脉泵入15 mL生理盐水,术中维持常规静吸复合麻醉.观察比较两组患者术后寒战发生情况、发生程度及血流动力学稳定情况.结果 D组术后寒战发生情况较S组轻,且程度明显减轻,差异均有高度统计学意义(均P < 0.01).D组血流动力学稳定性明显优于S组(P < 0.05).结论 右美托咪定能有效减少脾切除贲门血管离断术后寒战的发生,并能稳定血流动力学变化.
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