免疫抑制剂对移植术后血脂异常的研究

摘要

Cardiovascular and cerebrovascular complications is one of the major causes of transplanted organ death for the long-term survival patients with organ transplantation. In many factors of the resulting cardiac cerebral arteriosclerosis, hy-perlipidemia is one of the most important reasons. The immunosuppressive effects on serum lipids were reviewed in detail in this paper, including Corticosteroids, Cyclosporine, Tacrolimus, Sirolimus, Mycophenolate Mofetil, Azathioprine, and ultimately Mycophenolate Mofetil is one of the drugs which has minimal impact on blood lipids.%心脑血管合并症是导致长期存活器官移植患者移植器官功能死亡的主要原因之一.在导致心脑动脉硬化的诸多因素中,高脂血症是其中最重要的原因.文章详细地论述了不同免疫抑制剂对血脂的影响,包括皮质类固醇激素、环孢霉素、他克莫司、西罗莫司、吗替麦考酚酯、硫唑嘌呤等,最终发现吗替麦考酚酯是对血脂影响最小的药物之一.