Objective To analyze the resistant factors of multidrug-resistant organism (MDRO) in neonatal department of our hospital, in order to provide basis for clinical diagnosis and rational antibiotic use. Methods Specimen of drug-resistant bacterial strains in neonatal department of our hospital from January 2011 to December 2011 were analyzed retrospectively. Results The sputum specimens accounted for 87.5% in neonatal department, and the detection rate of drug-resistant bacterial strains in NICU was more than that in common ward; G" bacteria accounted for 83.3% in the majority of MDRO, G+ bacteria accounted for 16.7%; the first drug-resistant bacterial strains was klebsiella pneumoniae, accounting for 41.7%, and escherichia accounted for 33.3%, and MRSA accounted for 12.5%; carbapenem such as Imipenem were still the strongest antibiotics for klebsiella pneumoniae and escherichia, followed by the compound preparations added for beta -laetamase and cephamycin; MRSA preferred vancomycin. Conclusion We should enhance the cooperation of multiple discipline and department, and strengthen the monitoring of bacteria resistance and use rational antibiotic in order to avoid the increase of drug resistant bacterial strains caused by abuse of antibiotic.%目的 分析我院新生儿科多重耐药菌的耐药因素,为指导临床诊断及合理应用抗菌药物提供依据.方法 采用回顾性分析方法,对我院2011年1月～2011年12月新生儿科送检分离的耐药菌株标本进行统计分析.结果 我院新生儿科标本类型以痰液标本为主,占87.5%;新生儿重症监护病房(NICU)的耐药菌检出率高于普通病房;多重耐药菌以G-菌居多,占83.3%,G+菌占16.7%;耐药菌株数排在第1位的肺炎克雷伯菌占41.7%,第2位的大肠埃希菌占33.3%,第3位的耐甲氧西林金黄色葡萄球菌(MRSA)占12.5%;碳青霉烯类药物如亚胺培南仍是对大肠埃希菌和肺炎克雷伯菌作用最强的一类抗菌药物,其次为加β-内酰胺酶抑制剂的复方制剂和头霉素类药物.MRSA首选万古霉素治疗.结论 应增强多学科、多部门协作,加强细菌耐药监测,并合理规范使用抗菌药物,以避免滥用抗菌药物所致的耐药菌株的增加.
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