目的 探讨尿促卵泡素治疗特发性少弱精子症的临床疗效.方法 选取本院2008年1月～2011年6月收治的特发性少弱精子症男性不育患者94例,随机分为两组,采用口服葡萄糖酸锌片(70 mg/次,2次/d)和维生素E胶丸(100 mg/次,2次/d)治疗3个月的患者47例为对照组,在对照组口服药物治疗基础上联合使用注射用尿促卵泡素(75 IU/次,1次/3 d)肌内注射治疗3个月的患者47例为观察组,比较两组患者的各项临床指标并进行随访.结果 治疗后对照组患者精子密度、精子活动力、精子存活率明显增加,而精液量增加不明显,畸形精子率降低不明显.治疗后观察组患者精液量、精子密度、精子活动力、精子存活率明显增加,畸形精子率明显降低.治疗后观察组患者精液量、精子密度、精子活动力、精子存活率明显高于对照组,而观察组患者畸形精子率明显低于对照组.治疗后观察组患者总有效率和妊娠发生率均明显高于对照组(均P＜ 0.05).结论 采用尿促卵泡素治疗男性特发性少弱精子症不仅可以明显改善患者的精液量和提高精子密度,还可以增强患者精子的活动力和提高精子存活率,进而提高了患者配偶的妊娠发生率,是一种有效的治疗方法.%Objective To investigate clinical efficacy of idiopathic disease in the treatment with pure urinary FSH. Methods 94 idiopathic oligospermia and asthenospermia patients with male infertility were selected in the hospital from January 2008 to June 2011, who were randomly divided into two groups. 47 patients used oral zinc gluconate tablets (70mg/time, 2 times/d) and vitamin E capsules (100 mg/time, 2 times/d) in the treatment for 3 months as the control group. Basing on the control group oral drug therapy, 47 patients used purified urinary follicle stimulating hormone (75 IU/time, 1 time/3 d) intramuscular injection in the treatment for 3 months as the observation group. Various clinical indicators of two groups followed up were comparied. Results After treatment, the sperm density, sperm motility, sperm survival rate of patients in the control group increased significantly, while the semen volume did not significantly increase and abnormal sperm rate was not obvious. After treatment, the semen volume, sperm density, sperm motility, sperm survival rate of patients in the observation group increased significantly, while abnormal sperm rate decreased obviously. After treatment, the semen volume, sperm density, sperm motility, sperm survival rate of patients in the observation group were significantly higher than those in the control group, while abnormal sperm rate of patients in the observation group was lower than that in the control group. After treatment, total effective rate and pregnancy rate in the observation group were significantly higher than those in the control group. Adverse reaction rate in the observation group was significantly higher than that in the control group. The differences were statistically significant (P < 0.05). Conclusion Using pure urinary FSH in the treatment with male idiopathic oligospermia and asthenospermia patients not only can improve the semen volume and improve sperm density, but also can enhance patients' sperm activity and improve the sperm survival rate. That can improve the spouses of patients with pregnancy incidence rate, which is a safe and effective method of treatment.
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