Objective To investigate the causes, clinical features, classifications and liver function change of drug-induced liver injury (DILI) in the elderly. Methods one hundred and five inpatients with drug-induced liver injury in our hospital from October 2006 to October 2011 were retrospectively investigated. Results Among 105 DILI cases, there were 33 cases in the older group and 72 cases in middle-youth age group. Ihe latent period of DILI in the older group was from three days to four months. The most common drugs inducing DILI were Chinese traditional and herbal drugs, accounting for 27.62%. Drags used in heart diseases and inducing liver injury were more common in the older group (P < 0.01). In this study, 20(60.61%), 9(27.27%) and 4(12.12%) cases were designated as hepalocelluiar, oholesletic and mixed DILI in the older group, and 43 (59.72%), 12(16.67%) and 7(23.61%) in middle-youth age group, respectively. There were no significant differences between two groups in classifications. Conclusion Clinicians should raise the understanding of the DILI in the elderly, which is mainly caused by Chinese herbal drugs and antibiotics, with long latent period.%目的 探讨老年人药物性肝损伤的病因、分型和肝功能变化等特点.方法 回顾性分析2006年10月～2011年10月我院105例因药物性肝损伤住院患者的临床资料.结果 药物性肝损伤患者105例,老年组和中青年组分别为33例和72例;老年药物性肝损伤的潜伏期为3 d～4个月;导致药物性肝损伤最常见的药物为中药类(27.62%),老年组心血管系统用药比例高于中青年组(P<0.01);老年组肝细胞型为20例(60.61%)、胆汁淤积型9例(27.27%)和混合型4例(12.12%),中青年组分别为43例(59.72%)、12例(16.67%)和17例(23.61%).两组临床分型差异无统计学意义.结论 临床应提高对老年性肝病的认识,老年患者药物性肝损伤以中草药类及抗微生物药为主,潜伏期较长.
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