目的 探讨联合应用前列地尔对糖尿病肾病患者的临床疗效.方法 将2010年1～12月我院收治的66例患者随机分为研究组和对照组各33例.两组患者均常规行降糖、饮食控制、蛋白摄入限量等基础性治疗,并给予卡托普利口服治疗,研究组患者在此基础上加用前列地尔.结果 研究组患者治疗后总有效率为93.94%,明显高于对照组(63.64%),差异有统计学意义(P ＜ 0.05);两组患者治疗前各指标比较差异无统计学意义(P ＞ 0.05);治疗后两组患者各指标均有明显下降(P ＜ 0.05),但研究组血尿素氮(BUN)、空腹血糖(FPG)、白蛋白排泄率(UAER)明显低于对照组,差异有统计学意义(P ＜ 0.05).结论前列地尔对于治疗糖尿病肾病具有较好的临床效果,能够有效提高对肾功能的修复和保护作用.%Objective To investigate the clinical curative effects of combined Alprostadil in the treatment of patients with diabetic nephropathy. Methods 66 cases admitted to our hospital from January 2010 to December 2010 were randomly divided into study group and control group, with 33 cases in each group. Both groups of patients received routine blood glucose reduction, diet control, protein intake limit and other basic treatment as well as oral administration of Captopril. Patients of the study group received additional Alprostadil on the basis. Results The total effective rate of the study group was 93.94%, which was significantly higher than 63.64% of the control group, with statistically significant difference (P < 0.05); before the treatment, none of the indicators was significantly different between the two groups (P > 0.05); after the treatment, all the indicators of the two groups decreased significantly (P < 0.05), but blood urea nitrogen (BUN), fasting plasma glucose (FPG), urinary albumin excretion rate (UAER) of the study group were significantly lower than those of the control group, with statistically significant differences (P < 0.05). Conclusion Alprostadil shows good clinical curative effects in the treatment of diabetic nephropathy and can effectively promote the restoration and protection for of renal function.
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