Objective To perform case-control study to analyze the association between polymorphisms in IL-6 174G/C and IL-6 572 G/C and cononary artery disease.Methods A total of 103 CAD patients were collected,and 214 inpatients were enrolled as controls at the same time.PCR was performed to analyze the polymorphisms in IL-6 174G/C and IL-6 572 G/C.SPSS 11.0 was taken to analyze the data,and P ＜ 0.05 was considered as significant difference.Results Male,smoking,high BMI,hypertension and diabetes were the high risk factors of CAD (P ＜ 0.05).In addition,low TC,HDL-C and LDL-C and high TG contents were the high risk factors of CAD (P ＜ 0.05).The proportion of IL-6 572 C/C in cases (11.7％) was significantly higher than that in controls (2.8％),and there was significant difference between the two groups (P ＜ 0.05.When compared with the IL-6 572 G/G genotype,IL-6 572 C/C genotype significant increased the risk of CAD,and the adjusted OR (95％CI) was 5.10 (1.66-17.40).Conclusion Polymorphisms in IL-6 174 G/C are associated with risk of CAD,and individuals with IL-6 174 C/C can increase 5-folds risk of CAD.%目的 本研究采用病例对照方法采用PCR分析IL-6 174G/C和IL-6 572 G/C基因多态性与冠心病的相关性.方法 共收集了103例冠心病病例,选取214例同期住院患者为对照病例,采用PCR分析IL-6 174G/C和IL-6 572 G/C基因多态性,所有的分析均采用SPSS 11.0软件进行分析,以P＜0.05为差异有统计学意义.结果 男性、吸烟、高体重指数(BMI),糖尿病和高血压是冠心病的危险因素(P＜0.05).另外,低总胆固醇(TC)浓度,低高密度脂蛋白胆固醇(HDL-C)浓度、低密度脂蛋白胆固醇(LDL-C)浓度和高三酰甘油(TG)浓度是冠心病的危险因素(P＜0.05).IL-6 572 C/C基因型在病例组(11.7％)中的百分比显著性高于对照组(2.8％),差异有统计学意义(P＜0.05).而IL-6 572 C/C基因型与G/G基因型相比,C/C基因型能显著性的增加冠心病的风险,调整后的OR (95％CI)值为5.10(1.66～17.40) (P＜ 0.05).结论 IL-6 174 G/C基因多态性与冠心病发病风险有显著性的相关关系,携带IL-6 174 C/C基因型的个体患冠心病的风险是携带G/G基因型的5倍多.
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