Objective To investigate the correlation between proteinuria and CRP,TNF-α and IL-6 levels in patients with diabetic nephropathy.Methods 210 patients with diabetic nephropathy in the First People's Hospital in Guangzhou City Affiliated to Guangzhou Medical College from June 2008 to June 2012 were selected as diabetic group and divided into no albuminuria group (n =64),micro albuminuria group (n =87) and clinical albuminuria group (n =59) according to UAER results; 82 cases with physical examination in the same term were selected as control group;CRP,TNF-α and IL-6 level were compared among the groups.Results The levels of CRP [(4.79±0.96),(8.34±2.61),(12.58±4.27) mg/L],TNF-α [(1.64±0.31),(1.99±0.59),(1.99±0.59) ng/L],IL-6 [(24.53±6.93),(29.62±7.51),(29.62±7.51) ng/L] in no albuminuria group,micro albuminuria group and clinical albuminuria group were all higher than those in control group [(2.37±0.45) mg/L,(1.03±0.42) ng/L,(10.73±3.25) ng/L],the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01).Conclusion The level of CRP,TNF-α and IL-6 in patients with diabetic nephropathy has increase with the urinary protein excretion rate,it is right to use them as the basis for early diagnosis of diabetic nephropathy.%目的 研究糖尿病肾病患者蛋白尿与C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平的关系.方法 选择2008年6月～2012年6月广州医学院附属广州市第一人民医院治疗的糖尿病患者210例为糖尿病组,根据尿白蛋白排泄率(UAER)的测定结果分为无白蛋白尿组64例,微量白蛋白尿组87例和临床白蛋白尿组59例,选取同期健康体检者82例为对照组,比较各组间CRP、TNF-α和IL-6水平变化.结果 无白蛋白尿组、微量白蛋白尿组、临床白蛋白尿组的CRP[(4.79±0.96)、(8.34±2.61)、(12.58 ±4.27) mg/L]、TNF-α[(1.64±0.31)、(1.99±0.59)、(1.99±0.59)ng/L]、IL-6[(24.53±6.93)、(29.62±7.51)、(29.62±7.51) ng/L]水平均高于对照组[(2.37±0.45)mg/L、(1.03±0.42)ng/L、(10.73±3.25)ng/L],差异均有统计学意义(P＜0.05或P＜0.01).结论 糖尿病肾病患者的CRP、TNF-α和IL-6水平随尿蛋白排泄率的增加而增加,可作为糖尿病肾病早期诊断的依据.
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