Objective To compare the clinical effects in treating intractable vaginitis caused by Candida of elderly patients between Ketoconazole and Ketoconazole combined with Clotrimazole. Methods 86 elderly patients diagnosed with intractable vaginitis caused by Candida were divided into two groups. Patients from Ketoconazole group were given 200 mg Itraconazole daily for 9 days, while patients from Ketoconazole combined with Clotrimazole group were provided with 200 mg Itraconazole and one piece of Clotrimazole to input in vagina daily for 9 days. The improvement of symptoms and signs, scores of symptoms and signs, clinical effects, side effects and relapse between two groups were compared. Results After corresponding treatment, the improvement of symptoms and signs and scores of symptoms and signs were both improved (all P < 0.05). The clinical effects, side effects and relapse between two groups were not significantly different (P > 0.05). Combined group were significantly better than Ketoconazole group in symptoms and signs improvement after treatment for 4 weeks and 8 weeks (P < 0.05). Conclusion The clinical effect of Ketoconazole group and Ketoconazole combined with Clotrimazole group is equal. Combined group is only better than Ketoconazole group in short term symptoms and signs improvement.%目的 比较酮康唑单独治疗和酮康唑联合克霉唑栓治疗老年念球菌性阴道炎的疗效.方法 将86例老年念球菌性阴道炎患者分为酮康唑组和联合组.酮康唑组患者每日服用酮康唑200 mg,连续用药3 d为1个周期,连续治疗3个周期.联合组患者服药剂量、频次和周期同前;临睡前阴道深部内置1枚克霉唑栓进行联合治疗.比较两组患者治疗后的症状和体征改善状况、基于症状和体征的评分、临床疗效、不良反应和复发情况.结果 两组患者治疗后其症状和体征均显著改善,评分都显著降低,临床疗效都明显好转(均P ＜ 0.05);两组患者的临床疗效、治疗后复发情况和不良反应发生情况无统计学差异(P ＞ 0.05).联合组在治疗后4周和8周的念球菌性阴道炎症状缓解和体征改善评分显著低于酮康唑组(P ＜ 0.05).结论 酮康唑和酮康唑联合克霉唑栓治疗老年念球菌性阴道炎的疗效相当,酮康唑联合克霉唑栓治疗在治疗后短期症状和体征缓解方面优于单独使用酮康唑治疗.
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