NF-κB在胃癌组织中的表达与临床病理的相关性研究

摘要

Objective To detect the expression of nuclear factor κB in gastric cancer tissue (NF-κB) and explore its correlation with clinicopathologic. Methods From January 2004 to January 2009, 50 patients with gastric cancer and 50 cases without tumor in Sichuan Provincial People's Hospital were selected, then the expression of NF-κB in lesion tis-sue and adjacent tissues of patients with lung cancer and gastric mucosa tissue of non-tumer patients were detected with immunohistochemistry (SP method). The expression of NF-κB with different clinicopathological features were com-pared,and the 5-year survival rates were observed. Results The positive expression rates of NF-κB in lesion tissue and adjacent tissues of patients with lung cancer and in gastric mucosa tissue of non-tumer patients were respectively 76.0%(38/50),4.0%(2/50) and 16.0%(8/50),the differences were statistically significant(χ²=20.404, 43.511, 6.655,P<0.05),In lesion tissue, the expression of NF-κB was positive correlation with vascular invasion, degree of infiltration, lymph node metastasis and tumor size when the size was 5 cm below (r=0.318, 0.243, 0.315, 0.350;P=0.002, 0.002, 0.035, 0.001),but no correlation with the differentiated degree (r=0.119, P=0.242). 5-year survival rates of patients with low NF-κB expression was significantly higher than that with high NF-κB expression (P<0.05). Conclusion NF-κB expression is closely related with the invasion and metastasis in gastric cancer, and the detection of it is very impor-tant to monitor the condition and metastatic potential, and evaluate prognosis of gastric cancer.%目的：检测胃癌组织中核因子资B(nuclear factor kappa binding,NF-资B)的表达情况,探索NF-资B与临床病理的相关性。方法选取2004年1月~2009年1月四川省人民医院病理科收入的50例胃癌患者和同期的50例非肿瘤患者,应用免疫组织化学方法(SP法)检测胃癌患者病灶组织及癌旁组织、非肿瘤患者胃黏膜组织的NF-资B,比较分析不同临床病例特征者的NF-资B的表达情况,并比较不同的NF-资B表达情况者的5年生存率。结果胃癌患者胃癌组织、癌旁组织和非肿瘤患者胃黏膜组织中NF-资B蛋白阳性表达率分别为76.0%(38/50)、4.0%(2/50)和16.0%(8/50),差异均有统计学意义(字2=20.404,43.511,6.655,均P<0.05)；胃癌组织中NF-资B的表达与脉管侵犯、浸润程度、淋巴结转移、当肿瘤直径<5 cm时,与肿瘤大小呈正相关(r=0.318,0.243,0.315,0.350；P=0.002,0.002,0.035,0.001),与分化程度无相关性(r=0.119,P=0.242),非肿瘤患者NF-资B低表达者的5年生存率显著高于高表达者(P<0.05)。结论 NF-资B阳性表达与胃癌的侵袭、转移密切相关,检测NF-资B的表达对胃癌病情监测及转移潜能及预后估计等方面有重要参考价值。