多发性骨髓瘤(MM)伴椎管浸润临床罕见，治疗困难，目前国内外尚无推荐的标准治疗方案，仅见个案报道，预后差。化疗、手术、放疗为基本的治疗手段。本文总结分析2例MM伴椎管浸润病例的临床诊疗过程、疗效及病程的进展情况，并复习相关文献，进一步加深对MM伴椎管浸润的诊疗认识。及早发现、诊断和个体化治疗是改善预后的关键，患者一旦出现截瘫，治疗效果差，进展迅速，预后极差。%Multiple myeloma (MM) with intraspinal invasion is very rare in clinic, which is difficult to treat. No stan-dard treatments are recommended at home and abroad, and only case report can be found, which is poor prognostic. Chemotherapy, operation and radiotherapy are the basic treatments. To further deepen the understanding of the diagno-sis and treatment of MM complicated by spinal infiltration, clinical practice, curative effect and course of disease pro-gression of two cases of MM complicated with spinal infiltration are summarized and analyzed, and pertinent literature is reviewed. Early detection, diagnosis and individualized treatment are thought to be critical in improving prognosis. Once paraplegia happened in patients, the therapeutic efficacy and prognosis would be very poor, and the disease pro-gression would be rapid.
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