Caspase-1与骨关节炎的研究进展

摘要

骨关节炎的发病机制尚不完全清楚，目前认为软骨细胞死亡和细胞外基质的破坏是该病的主要病理改变。白介素（IL）-1β和IL-18在骨关节炎的发病过程中发挥着关键的作用，而IL-1β转化酶（Caspase-1）能将IL-1β和IL-18的前体加工成为成熟的活性形式，发挥二者的生物学作用，从而参与骨关节炎的发生发展。因此，Caspase-1在骨关节炎的发生发展中起着重要的作用，Caspase-1抑制剂有可能为骨关节炎的治疗提供新的策略。本文就Caspase-1与骨关节炎的相关研究进展作一综述。%The pathogenesis of osteoarthritis is not yet completely clear. It is recognized that the death of chondrocyte and the damage of extracellular matrix are the main pathological changes at present. Interleukin (IL)-1β and IL-8 play a vital role in the pathological process of osteoarthritis, while IL-1β invertase (Caspase-1) can process the precursor of IL-1β and IL-18 into ripe active form, play the biological effects of them, so as to participate in the occurrence and progress of osteoarthritis. Thus, Caspase-1 plays an important role in the occurrence and progress of osteoarthritis, Caspase-1 inhibitor may offer a new strategy for the treatment of osteoarthritis. This paper reviews the related research progress of Caspase-1 with osteoarthritis.