北京某高校教职工非酒精性脂肪性肝病的患病率及相关疾病分析

摘要

Objective To explore the prevalence rate of nonalcoholic fatty liver disease (NAFLD) and the relationship between NAFLD and other diseases,in order to provide useful information for the prevention and treatment of NAFLD.Methods 2140 staffs of Beijing Institute of Technology,who underwent medical examination from October to December in 2016 at Hospital of Beijing Institute of Technology,were selected as the study objects.For each case,the height,weight,and waist circumference were measured,the biological tests of liver function,kidney function,blood lipid and blood glucose were taken,and the abdominal ultrasonography was performed.Firstly,according to their age,they were divided into two groups:age ＜ 60 years (2099 cases) and age ≥ 60 years (41 cases).The prevalence rates of NAFLD between the two groups with different sex were compared.Then,according to the results of ultrasonography,there were 341 cases in NAFLD group and 1799 cases in non-NAFLD group.The prevalence rates of hypertension,diabetes,dyslipidemia,hyperuricemia and obesity between NAFLD group and non-NAFLD group were compared.Results The prevalence rate of NAFLD was 15.93％ cases (341/2140) in this study.The prevalence rate of NAFLD in male was significantly higher than that of female before the age of 60 (P ＜ 0.01),while there was no significant difference after the age of 60 (P ＞ 0.05).There was significantly higher morbidity rate of hypertension,diabetes,dyslipidemia,hyperuricemia and obesity in NAFLD group than that in non-NAFLD group (P ＜ 0.05).Conclusion The prevalence rate of NAFLD in this university is at a higher level.The occurrence of NAFLD is closely related to lipid metabolic disorders.It is also a systemic disease which often combines with varies metabolic disorders,such as hypertension,diabetes,dyslipidemia,hyperuricemia and obesity.Some necessary measures should be taken for proactive prevention and treatment of NAFLD.%目的 探讨非酒精性脂肪性肝病(NAFLD)的患病率以及同相关疾病的关系,为NAFLD的防治提供参考.方法 选取2016年10～12月在北京理工大学医院体检的北京理工大学在职教职工2140例作为研究对象,测量身高、体重、腰围,行肝功、肾功、血脂、血糖等生化检查,行腹部B超检查.根据年龄分为＜ 60岁组(2099例)和≥60岁组(41例),比较不同年龄、性别NAFLD的患病率.根据腹部B超检查结果,分为NAFLD组(341例)和非NAFLD组(1799例),比较两组高血压、糖尿病、血脂异常、高尿酸血症、肥胖的患病率.结果 NAFLD患病率为15.93％(341/2140).＜60岁男性NAFLD的患病率明显高于女性(P＜ 0.01),≥60岁男性与女性NAFLD的患病率差异无统计意义(P＞0.05).NAFLD组高血压、糖尿病、血脂异常、高尿酸血症、肥胖的患病率明显高于非NAFLD组,差异有统计学意义(P＜0.05).结论 该校在职教工NAFLD患病率较高.NAFLD的形成不仅和脂代谢障碍关系密切,而且易合并高血压、糖尿病、血脂异常、高尿酸血症、肥胖等多种代谢紊乱的全身性疾病,应采取必要措施积极防治.