Objective To investigate the efficacy of Danshen Chuanxiongqin Injection for the indexes of hemorheology,blood coagulation and oxidative stress after treatment with hyperbaric oxygen in elderly patients with cerebral embolism.Methods Eighty-six patients with cerebral embolism receiving treatment with hyperbaric oxygen in Affiliated Hospital of Yan'an University from January 2016 to January 2017 were randomly divided into observation group and control group by random number table method,with 43 cases in each group.All patients were given hyperbaric oxygen therapy,on basis of which,the observation group was added with Danshen Chuanxiongqin Injection.The treatment time of the two groups was 15 days.After treatment,the scores of national institutes of health stroke scale (NIHSS) and Barthel scores in the two groups were recorded,and the clinical efficacy was evaluated.Before and after treatment,the levels of blood coagulation indexes (prothrombin time,activated partial thromboplastin time,thrombin time,international normalized ratio),hemorheology indexes (whole blood high shear viscosity,plasma viscosity,haematocrit,fibrinogen,platelet adhesion rate),and oxidative stress indexes (superoxide dismutase,methane dicarboxylic aldehyde,total antioxidant capacity,glutathione peroxidase) in the two groups were detected.Results The scores of NIHSS in the observation group were lower than those of control group,Barthel scores were higher than those of control group (P ＜ 0.05).The total effective rate of observation group was higher than that of control group (P ＜ 0.05).After treatment,the levels of blood coagulation indexes,hemorheology indexes and oxidative stress indexes in the two groups were significantly improved compared with those before treatment,and the improvement of observation group was better than that of control group (P ＜ 0.05).Conclusion Danshen Chuanxiongqin Injection combined with hyperbaric oxygen in the treatment of cerebral embolism has better effects,which can significantly improve the hemorheology indexes,and it is worthy of further exploration.%目的 探讨丹参川芎嗪注射液对老年脑栓塞患者高压氧治疗后血液流变学、凝血及氧化应激指标的影响.方法 采用随机数字表法将2016年1月～2017年1月于延安大学附属医院需接受高压氧治疗的86例老年脑栓塞患者随机分为观察组和对照组,每组43例.所有患者均给予高压氧治疗,观察组在此基础上给予丹参川芎嗪注射液,两组治疗时间为15 d.治疗后记录两组患者美国国立卫生研究院脑卒中量表(NIHSS)评分及Barthel指数,评价临床疗效;治疗前后分别检测两组患者凝血指标(凝血酶原时间、活化部分凝血活酶时间、凝血酶时间及国际标准化比值)、血液流变学指标(全血高切黏度、血浆黏度、血细胞比容、纤维蛋白原及血小板黏附率)及氧化应激指标(超氧化物歧化酶、丙二醛、总抗氧化能力与谷胱甘肽过氧化物酶).结果 观察组NIHSS评分明显低于对照组,Barthel指数明显高于对照组(P＜0.05).观察组总有效率明显高于对照组,差异有统计学意义(P＜0.05).治疗后,两组患者凝血指标、血液流变学指标及血清氧化应激指标均较治疗前明显改善,且观察组改善程度明显优于对照组(P＜ 0.05).结论 丹参川芎嗪注射液联合高压氧治疗老年脑栓塞具有较好的临床效果,且能够有效改善患者血液流变学指标,值得进行深入探讨.
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