生物体液挥发性有机化合物分析研究进展

摘要

分析呼出气体、血液、汗液、尿液、唾液、胸腔积液、脑脊液、粪便等挥发性有机化合物是最新发展起来用于评估健康状况、疾病筛查和诊断的一种方法.近几年来,这种方法因其非侵入性、快速、操作简单方便、廉价以及患者良好的耐受性等优点,不但引起越来越多研究者的注意,而且扩展了新的研究领域.目前,肺癌呼出气、血液、尿液等代谢组学的研究表明烷烃、芳香烃、含氧有机化合物具有一定诊断价值,并在各种癌症中已经确定和某些特殊的挥发性有机化合物之间存在联系.%Analysis of volatile organic compounds in exhaled breath,blood,sweat,urine,saliva,pleural effusion,cerebrospinal fluid,stool is a new method that was used for the assessment of health status,disease screening and diagnosis.In recent years,this method has the advantages of non-invasive,rapid,convenient operation,cheap and patients with good tolerance.The analysis of volatile organic compounds has attracted more and more attention of researchers and expanded a new research field.At present,the metabolomics research of lung cancer in exhaled breath,blood and urine show that alkanes,aromatic hydrocarbons,oxy-compound has a certain diagnostic value.There is also a link between identified various types of cancer and some special volatile organic compounds.