评估SPECT测定不同年龄段健康人肾小球滤过率的准确性

摘要

目的:评估SPECT测定不同年龄段健康人肾小球滤过率(GFR)的准确性.方法:以232例北京地区社区健康居民为研究对象,分别采用双血浆法和99Tcm-二亚乙基三胺五乙酸(99Tcm-DTPA)肾动态显像法测定肾GFR(GFRdt和GFRGates).以GFRdt为参照标准,分析比较SPECT测定20～29岁、30～39岁、40～49岁、50～59岁、60～69岁及＞70岁的6个不同年龄组健康人肾小球率过滤的准确性.结果:16个不同年龄组所得GFRGates与GFRdt均具有显著性差异.2.6个不同年龄组所得GFRGates均明显低于GFRdt,其中30～39岁年龄段GFRGates与GFRdt的差异最大,差异均值为(-34.26±20.79);＞70岁年龄组GFRGates与GFRdt的差异最小,差异均值为(-9.48±10.85).③30～39岁组GFRGates与GFRdt相关性(r=0.42)最差;＞70岁组GFRGates与GFRdt相关性(r=0.81)最好.结论:SPECT测定20～49岁健康人GFR的准确性较差,测定≥50岁健康人GFR的准确性较好,其中≥70组准确性最好.%Objective: To estimate the accuracy of SPECT determination glomerular filtration rnrate in different age healthy groups. Methods: Totally 232 Beijing community health residents rnwere selected as the research subjects. Two-sample method and 99Tcm-DTPA dynamic renal imaging were used for rndetermination of GFR (GFRdt and GFRGates, respectively). GFRdt as the reference standard, compare the accuracy of six rndifferent age groups GFRGates which get by SPECT Results: ①There were significant differences between GFRdt and rnGFRcates on six different age groups. ②GFRGates from Six different age groups were significantly lower than those of GFRdt.rnThe difference in the group of 30-39years between GFRdt and GFRGates is maximum, the mean difference is (-34.26±20.79)rnml/(min·1.73m)2. The difference in the group of >70years between GFRdt and GFRGates is minimum, the mean difference rnis (-23.62± 18.60) ml/(min·1.73m)2. ③GFRdt and GFRgates derived from the group 30-39years had the worst correlation rn(r=0.42). GFRdt and GFRGates derived from the group >70years had the best correlation (r=0.81). Conclusion: Thernaccuracy of GFR which got by SPECT is poor in 20-49years health group, it is better in >50 years health group, while it is the best in >70 years health group.