Objective: To dicuss the unusual problem on synthesis of 18F-FDG in domestic PET-18F-FDG-IT-N module. Methods: We analyzed data of synthesis, the low yield of synthesis was researched through two sides of the synthesis parameters of 18F-FDG and the hardwares of module. Results: To find the optimum parameters to improve the yield of synthesis, the uncorrected synthesis yield is stablized in 57-62%. It provide references to revise the module to analyze the hardwares. Conclusion: In general, activation of QMA, temperature of nucleophilic reaction, dosagernof precursor, time of transmission target will influence the yield of synthesis. The paper can provide the reference in F-FDGrnsuccessful synthesis and the module revising.%目的:研究国产PET-18F-FDG-IT-N四合一模块在合成18F-FDG中遇到的异常问题.方法:在1年多的模块运行中,利用合成中的数据对比分析,分别从模块运行的关键参数和硬件两方面分析产生低产率的原因,改进了阴离子交换树脂柱(QMA)的活化方法、亲核反应的温度、前体用量和传靶的时间参数优化实验条件.结果:得出了该模块在合成18F-FDG时的最优化的参数,从而使不校正合成产率能稳定在55%～62%,同时降低了合成的故障率.从模块运行中泵的维护、反应管的形状、模块本身的分析,为模块的改进提供参考.结论:QMA的活化、亲核反应的温度、前体用量和传靶的时间都影响合成的产率,优化可以使合成的产率提高5%～10%,研究的结果为高产率成功合成18F-FDG和厂家模块的修改提供了参考.
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