目的：探讨二甲双胍和α-硫辛酸合用治疗Ⅱ型糖尿病的疗效。方法：将Ⅱ型糖尿病患者随机分为观察组和对照组。观察组使用二甲双胍和α-硫辛酸合用治疗；对照组单用二甲双胍治疗，比较两组患者疗效。结果：观察组与对照组比较：治疗15 d后各项指标无显著性差异(t=5.32，P＞0.05)；治疗30 d后观察组各项指标明显下降，与对照组比较差异明显(t=9.12，P＜0.05)；治疗60 d后差异显著(t=10.73，P＜0.05)。两组不良反应发生率比较无显著性差异。结论：二甲双胍与α-硫辛酸合用后的效果明显强于对照组。%Objective: To investigate the combination of metformin and α-lipoic acid on the treatment of type Ⅱ diabetic patients. Methods: Type Ⅱ diabetes were randomly divided into treatment group and control group. Observation group metformin α-lipoic acid combination therapy, the control group was treated with metformin, l Two groups were compared efficacy. treatment two weeks after the indicators, the indicators of the observation group was significantly decreased after one month of treatment, with the obvious differences in the control group (t=9.12, P=<0.05), treatment Two months later a significant difference (P<0.05). The two groups the incidence of adverse reactions was no significant difference (P>0.05). Conclusion: The effect of the combination of metformin and α-lipoic acid significantly stronger than a single group.
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