鼻咽癌64排CT表现与bcl-2蛋白表达关系的研究

摘要

目的 研究bcl-2蛋白表达与鼻咽癌64排CT表现的关系.方法 经活检病理证实的鼻咽癌30例,均行64排螺旋CT扫描,收集CT征象,采用免疫组织化学方法检测bcl-2蛋白表达情况,并分析CT征象与其bcl-2蛋白表达的相应关系.结果 bcl-2蛋白阳性表达率在鼻咽癌单侧壁肿块组与多侧壁肿块组分别为72.22%与83.33%,差异无显著性意义(P>0.05);在咽旁脂肪间隙消失组与无咽旁脂肪间隙消失组分别为100%与11.11%,差异有显著性意义(P<0.05);侵及后鼻道组与无侵及后鼻道组分别为93.75%与64.27%,差异有显著性意义(P<0.05);侵及上颌窦组与无侵及上颌窦组分别为89.47%与54.54%,差异有显著性意义(P<0.05).在颅底骨质破坏组与无颅底骨质破坏组,bcl-2蛋白阳性表达率分别为100%与37.5%,差异有显著性意义,(P<0.05),颈部淋巴结转移组与无颁部淋巴结转移组分别为80%与75%,差异无显著性意义(P>0.05).结论 bcl-2蛋白在鼻咽癌的发生、发展中起重要作用,其阳性表达与鼻咽癌的浸润深度有一定的相关性,因此bcl-2蛋白表达率可作为评价鼻咽癌CT表现恶性程度的指标.%Objective To study the relationship between the expression of bcl-2 and 64-CT findings of nasopharyngeal carcinoma (NPC). Methods 30 patients of NPC were confirmed by biopsy with 64-CT scanning, then the relationship between the expressions of bcl-2 and CT features was analyzed. Results The positive expression rates of bcl-2 were 72.22％ and 83.33％ in the single lateral wall and the multiple lateral wall of nasopharynx (P＞0. 05) respectively. The positive expression rates of bcl-2 were 100. 00％ and 11.11％ in para pharyngeal space narrowing respectively (P＜0. 05).It were 93.75％ and 64.27％ in posterior naris involved and without(f ＜0. 05).It were 89.47％ and 54.54％ in lower pharyngeal involved and without(p＜0. 05).It were 100.00％ and 37. 50％ in bone destruction of skull base and without(f＜0. 05). It were 80.00％ and 78.57％ in lymph node metastasis in neck and without(P＞0. 05 ).Conclusion Bcl-2 might play an important role in development of nasopharyngeal carcinoma. Bcl-2 proiein expression was correlated with invasive depth and prognosis metastasis.Bcl-2 could be served as indicator for predicting prognosis and malignancy of CT findings of nasopharyngeal carcinoma.