Wernick脑病的MRI诊断分析

摘要

目的：探讨MRI对Wernick脑病的临床诊断价值。方法回顾性分析2012年7月～2013年9月经临床证实的15例Wernick脑病患者的临床资料及MRI表现，其中5例患者同时行弥散加权成像（DWI），10例患者治疗后行MRI复查，并对治疗前后病灶的MRI表现进行对比。结果15例患者出现不同程度的两侧第三、四脑室旁、乳头体、背侧丘脑、中脑导水管周围白质区对称性异常信号。病灶表现为T1WI像呈低信号，T2WI像呈高信号，FLAIR序列呈明显高信号，DWI扫描呈高及等信号，治疗后病情明显好转。结论Wernick脑病具有特征性MRI表现，MRI对此病的诊断和预后判断具有重要价值。%Objective To investigate the effectiveness of MRI (Magnetic Resonance Imaging) in clinical diagnosis of Wernicke’s encephalopathy. Methods Clinical data and MRI manifestations of 15 patients with Wernicke’s encephalopathy who had been conifrmed clinically from July 2012 to September 2013 in the hospital were retrospectively reviewed. Among these patients, DWI (Diffusion Weighted Imaging) was performed in 5 patients;MRI re-examinations were carried out in 10 patients to compare the MRI ifndings before and after the treatment. Results Symmetrical abnormal signal intensity was displayed to a different extent in the third and fourth bilateral ventricles, corpus mamillare, dorsal thalamus and periaqueductal white matter in all the cases. MRI revealed low-intensity lesions on T1WI images;these were high-intensity on T2WI, FLAIR (Fluid-Attenuated Inversion-Recovery) and DWI images. The lesions were significantly improved after the treatment. Conclusion The Wernicke’s encephalopathy presents typical MRI ifndings. MRI is valuable for its diagnosis and prognosis.