重度妊高征孕妇血清β-hCG及HPL水平测定与新生儿出生情况的关系

摘要

目的:探讨重度妊娠高血压综合征(妊高征)血清β绒毛膜促性腺激素(β-hCG)、胎盘泌乳素(HPL)水平及新生儿出生情况之间的关系.方法:用放射免疫法测定102例正常妊娠妇女与102例重度妊高征妇女血清β-hCG及HPL水平,并对两组新生儿出生时情况进行比较.结果:正常妇女血清β-hCG为12.04±5.62μg/L,妊高征妇女血清β-hCG为30.29±15.12μg/L,两组比较差异有显著性(P＜0.05).妊高征组新生儿头围、体重及身高与正常组比较有显著差异,P＜0.01和P＜0.05.B-hCG异常升高易引起妊娠并发症,影响新生儿预后.正常妊娠妇女血清HPL水平为6.18±3.27mg/L,与妊高征妇女(6.08mg/L±4.06mg/L)相比无显著性差异(P＞0.05).结论:重度妊高征时血清中β-hCG水平可反映胎盘功能受损,并且与新生儿发育密切相关.%Objective:To study the level of beta-Human chorionic gonadotropins(β-hCG) and human placental lactogen (HPL) in serum of gravidas with severe pregnancy-induced hypertension(SPIH) and the relationship between their level and the neonate's condition.Methods:The level of β-hCG and HPL was measured by radio immunoassay in 102 cases of normal gravidas and 102 cases of the ones with PIH ,and the comparison of neonate's condition in two groups was performed.Results:β-HCG level in serum of gravidas with pregnancy-induced hypertension(PIH)(30.29±15.12μg/L) was significantly higher than the one of normal gravidas (12.04±5.62μg/L,P＜0.05).Neonate's head circumference, length and weight in normal group had significant difference with those of PIH group(P＜0.01 and P＜0.05). The abnormal increase of β-HCG level could easily lead to pregnancy complications to affect the neonate's prognosis. There was no significant difference of HPL level in serum between PIH(6.08±4.06mg/L) group and normal group(6.18±3.17mg/L, P＞0.05).Conclusions:The level of β-HCG in serum of gravida with SPIH can reflect the degree of functional impairment of the placenta and affect neonate's growth.