Hemostatic genes in symptomatic and hidden forms of thrombotic complications in obstetrics

摘要

Hemostatic genes in symptomatic and hidden forms of thrombotic complications in obstetrics.In given article we present the results of genetic testing for the factors of hemostasis in 30 patients during pregnancy and postnatal period which constitute a single group due to common mechanisms of complications(thrombosis in placenta,central or peripheral veins)and clinically manifested by severe preeclampsia,intrauterine growth restriction,premature detachment of normally situated placenta,venous thrombosis during pregnancy and after delivery.We detectedС677Тpolymorphism of MTHFR gene in 33.3%,F5 G1691A in23.3%,F1G455A in 36.7%.The most frequent mutations were in genes of anticoagulant system:PAI-1 gene(93.3%in a general group;100%in the group of women with thrombosis),ACE gene(60%),ITGB(40%).In majority of observed cases we defined combinations of mutations of different genes.In all women of the study complications developed on a background of risk factors such as caesarian section,infection,hormonal therapy,bed regiment.We consider that both genetic polymorphisms and risk factors of thrombosis should be detected in early terms of pregnancy and presence of their combination requires a thromboprophylaxis during pregnancy and after delivery,especially after Cesarean section.