Objective To investigate the clinical value of ring finger latency difference method combined with the second lumbrical muscle-interosseous muscle test for diagnosis of carpal tunnel syndrome. Methods From January 2014 to May 2015, 69 patients was diagnosed as carpal tunnel syndrome (88 limbs) using conventional electrophysio-logical method, ring finger incubation difference comparison method and lumbrical muscle-interosseous muscle exa-mination method respectively. The positive detection rates of the latter two methods were compared with that of the traditional electrophysiological method. Results Among the 64 limbs of typical cases, 47 limbs showed median nerve electrophysiological abnormalities, 53 limbs had abnormalities by ring finger latency difference method, 55 patients showed abnormalities in lumbrical muscle-interosseous muscle examination, 60 limbs were abnormal in the combi-nation of the three methods. In the 24 limbs of atypical cases, median nerve electrophysiological abnormality oc-curred in 15 limbs, 21 limbs were abnormal in ring-finger incubation difference comparison method, 20 cases were abnormal by lumbrical muscle-interosseous muscle method, and 22 limbs were abnormal in the combination of the three methods. Conclusions A combination of ring finger incubation difference comparison method and lumbrical muscle-interosseous muscle method can significantly improve the detection rate of carpal tunnel syndrome. It is wor-thy of clinical application.%目的：探讨行环指潜伏期差值比较法联合第二蚓状肌-骨间肌法检查诊断腕管综合征的临床价值。方法选取2014年1月-2015年5月新疆石河子市人民医院收治的腕管综合征患者69例（88侧），均应用常规电生理方法以及环指潜伏期差值比较法、蚓状肌-骨间肌检查法检测，分别比较两种方法与传统电生理方法检出阳性率。结果64侧临床典型病例，正中神经常规电生理异常47侧；环指潜伏期差值比较法异常53侧；蚓状肌-骨间肌法异常55侧；联合3种方法异常60侧。24侧不典型病例，正中神经常规电生理异常15侧；环指潜伏期差值比较法异常21侧；蚓状肌-骨间肌法异常20侧；联合3种方法异常22侧。结论联合应用环指潜伏期差值比较法及蚓状肌-骨间肌法可明显提高腕管综合征检出率，值得临床应用。
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