Objective To appraise the efficacy of Acarbose at lunch in treatment of type 2 diabetes with inadequate glycemic control after lunch treated with Insulin Lispro Mix25 before breakfast and supper. Methods Eighty-six cases with type 2 diabetes mellitus, who were treated with Insulin Lispro Mix25 Injection before breakfast and supper but still had inadequate glycemic control after lunch (>10 mmol/L), were randomly divided into two groups. The patients in the group A were added with Acarbose 50-100 mg at lunch to improve post-prandial blood glucose. The patients in the group B were added with Insulin Lispro Mix25 Injection 0.1-0.3 u/kg before lunch to improve postprandial blood glucose. After 2 weeks, the changes of seven-point blood glucose spectrum (before three meals, 2 h after three meals, at bedtime) and the frequency of hypoglycemia were com pared between the two groups. Results The rate of the patients reaching the standard level of postprandial 2-h blood glucose after lunch was not significantly different between the group A and the group B (86.05%vs 88.37%, >0.05). Comparison of the seven-point blood glucose spectra of the two groups showed that the postprandial 2-h blood glucose after supper in the group B was significantly lower than that in the group A [(6.1 ± 1.1) mmol/L vs (7.8 ± 1.0) mmol/L, <0.05], while the blood glucose levels at other time points were not different between the two groups. The frequency of hypoglycemia in the group A was significantly lower than that in the group B (4.65% vs 18.60%, <0.05). Conclusions Application of Acarbose at lunch can effectively control the postprandial 2-h blood glucose after lunch, and decrease the frequency of hypoglycemia.%目的 观察拜唐苹中餐时顿服对使用优泌乐25早、晚餐前注射的中餐后血糖控制不佳的2型糖尿病患者的疗效.方法 选取优泌乐25早、晚餐前皮下注射,早、晚餐前血糖基本控制,但中餐后2 h血糖控制不佳(>10 mmol/L)的2型糖尿病患者86例,随机分为两组:A组维持早、晚胰岛素剂量不变,中餐时增加拜唐苹1次顿服,50~100 mg;B组维持早、晚胰岛素剂量不变,中餐前增加1次优泌乐25(0.1~0.3 u/kg体重).2周后比较7:00血糖谱(3餐前、3餐后2 h、睡前)变化及低血糖发生频率.结果 ①两组中餐后2 h血糖达标率比较:A组为86.05%,B组为88.37%,两组比较,差异无统计学意义(>0.05);②两组7:00血糖值比较:A组晚餐后2 h血糖(7.8±1.0)mmol/L,B组(6.1±1.1)mmol/L,两组比较,差异有统计学意义(<0.05),两组3餐前、早餐后2 h、中餐后2 h、睡前血糖比较,差异无统计学意义;③低血糖反应:A组为4.65%,B组为18.60%,两组比较,差异有统计学意义(<0.05).结论 采用优泌乐25早、晚餐前皮下注射的中餐后2 h血糖控制不佳者,中餐时增加拜唐苹1次顿服与中餐前增加1次优泌乐25注射,控制血糖疗效相当,低血糖风险减少.
展开▼
