Objective: To explore the risk factors of psoriasis among Chinese, in order to provide with clues for the control and further studies on the pathogenesis of psoriasis. Methods; VIP, CBM, CNKI and Wanfang data were electronically searched, to collect the case- control trials on risk factors of psoriasis during 1994 to August 2012. Meta analysis was conducted by STATA 11.0 software. Results: Ten studies including 2763 patients and 2795 controls Were identified. Meta analysis showed that the pooled OR values (95% CI) of the risk factors were moisture 3.92 (2.69, 5.71), infection 3.36 (2.31, 4.89), trauma 2.84 (1.91, 4.21), alcohol intake 2.80 (2.03, 3.87), endocrine changes 1.02 (0.46, 2.26), eating fish and shrimp 2.06 (1.55, 2.74), mental stress 3.21 (2.59, 3.97), smoking 1.67 (0.92, 3.02), vaccination 2.44 (1.48, 4.00), surgery 1.20 (0.81, 1.77), tea 0.83 (0.67, 1.02), psoriasis family history 9.30 (6.18, 13.98), chemical stimulus 1.91 (0.69, 5.25), eating pungent food 1.58 (0.99, 2.51). Conclusion: Moisture, infection, trauma, alcohol intake, eating fish or shrimp, mental stress, vaccination, psoriasis family history are amongst the risk factors for psoriasis in Chinese, while the effects of endocrine changes, smoking, surgery, tea, chemical stimulus and eating pungent food need further study.%目的:分析国内银屑病患者发病的危险因素,为银屑病的预防控制及其病因学研究提供线索.方法:电子检索中文科技期刊全文数据库、中国生物医学文献数据库、中文学术期刊全文数据库和万方数据库,辅以文献追溯等方法,全面收集1994至2012年8月国内发表的关于银屑病发病危险因素的病例对照研究,应用STATA 11.0软件进行Meta分析.结果:共10篇文献符合纳入标准,累计病例2763例,对照2795例.Meta分析结果显示各因素合并比值比(OR)及其95％ CI分别为:受潮3.92(2.69,5.71),感染3.36(2.31,4.89),外伤2.84(1.91,4.21),饮酒2.80(2.03,3.87),内分泌变化1.02(0.46,2.26),食鱼虾2.06(1.55,2.74),精神紧张3.21(2.59,3.97),吸烟1.67(0.92,3.02),接种疫苗2.44(1.48,4.00),手术1.20(0.81,1.77),饮茶0.83(0.67,1.02),家族史9.30(6.18,13.98),化学刺激1.91(0.69,5.25),食辛辣1.58(0.99,2.51).结论:潮湿、感染、外伤、饮酒、食鱼虾、精神紧张、接种疫苗、家族史是诱发银屑病的危险因素,而尚不能认为内分泌变化、吸烟、食物过敏、手术、饮茶、化学刺激、食辛辣与银屑病的发病有关.
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