白芍总苷治疗系统性红斑狼疮的疗效及对CD11 a表达的影响

摘要

Objective:To assess the efficacy of total glucosides of paeony (TGP) in the treatment of sys-temic lupus erythematosus ( SLE) and the effects on the levels of CD11a. Methods: Forty two patients with SLE were treated with metacortandracin 0.5~1 mg/kg.d,and of them 21 patients were treated with additional TGP, 1.8 g/d for 3 months. The systemic lupus erythematosus disease activity index (SLEDAI) was assessed and the level of CD11a was detected by RT-PCR before and after treatment. Results: SLEDAI and the level of CD11a in all patients were significantly decreased after treatment, especially in the TGP group ( P<0.05) . There was no significant difference in adverse reaction in the patients treated with additional TGP . Conclusion:TGP has an additional therapeutic effect in combination with steroid in the treatment of SLE and does not increase the incidence of adverse reactions.%目的：：评价白芍总苷(TGP)治疗系统性红斑狼疮(SLE)的疗效及对CD11a基因表达的影响。方法：42例SLE患者口服泼尼松0.5~1 mg/(kg.d),其中21例加用TGP,1.8 g/d,疗程3个月。治疗前后进行系统性红斑狼疮疾病活动指数( SLEDAI)评分,RT－PCR检测CD11a表达水平。结果：与治疗前相比,患者SLEDAI评分和CD11a基因的表达水平均显著下降,加用TGP的患者下降更明显( P<0.05)。加用TGP患者与未加用患者不良反应发生率无明显差异。结论：泼尼松加用TGP能提高治疗系统性红斑狼疮疗效,且不增加不良反应发生率。