儿童急性泛发性脓疱型银屑病外周血参数分析

摘要

Objective:To determine the changes of the levels of peripheral blood platelet parameters, Cre-active protein (CRP) and eosnophils (EOS) in children with acute generalized pustular psoriasis (AGPP). Methods:The levels of peripheral blood platelet parameters, CRP and EOS in 41 children with AGPP, 37 healthy children and 31 children with psoriasis vulgaris were detected. Results: The levels of PLT count, platelet hematocrit ( PCT) and CRP in the active stage of AGPP group were higher than those in the other two groups ( P<0.05) . The mean platelet volume ( MPV) and EOS percentage were lower than those in the other two groups (P<0.05). There was no significant difference of EOS count among the three groups (P>0.05). The levels of PLT count, PCT and CRP in the recovery stage of AGPP were lower than those in active stage. Conclusion:Platelet parameters and CRP level could be as assistant indicators in monitoring the progression of children with AGPP.%目的：：明确儿童急性泛发型脓疱性银屑病(AGPP)血小板参数、C反应蛋白(CRP)及嗜酸粒细胞水平变化。方法：检测41例儿童AGPP患者、37例健康儿童对照及31例儿童寻常型银屑病患者( PV)血小板参数、CRP及嗜酸粒细胞水平。结果： AGPP进展期PLT计数、血小板压积( PCT)， CRP均显著高于儿童PV患者及儿童正常对照组( P<0.05)。进展期AGPP患者嗜酸粒细胞百分比和平均血小板体积(MPV)显著低于其他两组(P<0.05)。嗜酸粒细胞计数与对照组无明显差异(P>0.05)。消退期AGPP患者PLT计数、PCT及CRP显著低于进展期AGPP患者( P<0.05)。结论：血小板参数及CRP水平可作为AGPP病程进展及治疗评价的参考指标。