中国汉族大疱性皮肤病GLCCI1变异体与糖皮质激素不敏感无相关性

摘要

Objective:To investigate the association between GLCCI1 gene and GC sensitivity in Chinese patients with bullous diseases. Methods:A total of 187 subjects were divided into GC-sensitive group ( con￣trol dose ≤60 mg, n=129 ) and GC-insensitive group ( control dose ≥150 mg, n=58 ) . Single SNP ( rs37973) was genotyped with TaqMan SNP Genotyping Assay Kit on the GeneAmp 7900 Sequence Detection System using specific TaqMan probes. The statistical analysis was performed using logistic regression in PLINK. Results:We failed to detect rs37973 variation in the patients with GC-insensitive bullous diseases (P=0.7881, odds ratio=1.062). Conclusion: There is no association between GLCCI1 and glucocorticoids sensitivity in Chinese patients with bullous diseases.%目的：：应用基因分型技术分析中国汉族种群大疱性皮肤病GLCCI1变异体与糖皮质激素不敏感的相关性。方法：将187例大疱性皮肤病患者根据控制病情所需糖皮质激素用量分为实验组(糖皮质激素量≤60 mg,n＝129)与对照组(糖皮质激素量≥150 mg,n＝58),应用Taqman genotyping技术对研究对象进行位于GLCCI1基因的SNP rs37973基因分型,数据资料应用PLINK软件进行logistic回归分析。结果：未发现GLCCI1基因的SNP rs37973与中国汉族种群大疱性皮肤病中糖皮质激素不敏感存在显著相关性( P＝0.7881, OR＝1.062)。结论： GLCCI1变异体与中国汉族种群大疱性皮肤病糖皮质激素不敏感无显著相关。