Caspase－3在皮肤鳞状细胞癌及光线性角化病中的表达

摘要

目的：：检测Caspase－3在皮肤鳞状细胞癌及光线性角化病组织中的表达。方法：应用免疫组化法检测16例皮肤鳞状细胞癌皮损、27例光线性角化病皮损及24例正常皮肤组织中Caspase－3蛋白的表达。结果： Caspase－3在皮肤鳞状细胞癌、光线性角化病及正常皮肤组织的表达率分别为37.50％,51.85％,79.17％,其表达含量在皮肤鳞状细胞癌、光线性角化病、正常皮肤组织逐渐增加。结论： Caspase－3蛋白表达下调可能参与皮肤鳞状细胞癌及光线性角化病的发病过程。%Objective:To detect the level of Caspase-3 in the lesions of cutaneous squamous cell carcino-ma and actinic keratosis. Methods:The level of Caspase-3 in 16 lesions of cutaneous squamous cell carcino-ma, 27 lesions of actinic keratosis and 24 normal skin was detected by immunohistochemistry method. Re-sults:The positivity rate of Caspase-3 in the lesions of cutaneous squamous cell carcinoma, actinic keratosis and normal skin tissues was 37.50%, 51.85% and 79.17% respectively. The expression quantity of Caspase-3 in the lesions of cutaneous squamous cell carcinoma, actinic keratosis and normal skin was increased gradu-ally. Conclusion:The down-regulated expression of Caspase-3 may be involved in the pathogenesis of cuta-neous squamous cell carcinoma and actinic keratosis.