Caspase-3 and Caspase-8 are important proteins in the process of apoptosis. Caspase-8 can start apoptotic reaction which can mediate apoptosis in a variety of ways. Caspase-3 can accelerate cell apop-tosis after activation. The new studies reported high expression of Caspase-3, Caspase-8 in lichen planus le-sions, especially in the basal layer which showed that Caspase-3, Caspase-8 might be involved in the apop-totic response process of lichen planus.%Caspase-3和 Caspase-8作为含半胱氨酸的天冬氨酸蛋白水解酶家族成员,是参与细胞凋亡过程的两个重要蛋白。 Caspase-8是重要的凋亡启动蛋白,可通过多种途径介导凋亡反应的发生, Caspase-3作为凋亡过程中的执行者,活化后可以加速细胞凋亡的发生。最新研究发现 Caspase-3和Caspase-8在扁平苔藓皮损处(特别是基底层处)高表达,表明两者可能参与了扁平苔藓的凋亡过程,并导致了本病的病理变化。
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