A 73-years-old male presented with black macula on the glans for 4 years and hematuria for half a month. Pathological examination of the lesions showed that the tumor cells were mainly located under the epidermis, large irregular nuclei and a large number of melanin granules in the cytoplasm. Immunohistochem-istry was positive for S-100, HMB45, Melan-A and SOX-10. Ki67 was positive in about 50% melanocytes.%患者,男,73 岁.龟头部黑色斑疹4年,血尿半月.皮损病理检查示: 镜下见肿瘤细胞主要位于表皮下,细胞核大且不规则,胞质中含大量黑色素颗粒.免疫组化:肿瘤细胞S-100(+),HMB45 (+), Melan-A(+), SOX-10(+),Ki67约50%阳性.
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