生殖支原体耐药位点与治疗研究进展

摘要

Mycoplasma genitalium(Mg) is widely recognized as one of the important pathogens and it may cause non-gonococcal urethritis in males. Tetracyclines,macrolides and quinolones are effective in the treat-ment of the disease. Many recent studies have shown that resistance to doxycycline and azithromycin in Mg is more serious,and there are more reports of treatment failure with moxifloxacin. The update of the drug resist-ance loci of Mg and treatment is reviewed in this paper.%生殖支原体是引起男性非淋菌性尿道炎的重要病原体之一,主要的治疗药物包括四环素类、大环内酯类、喹诺酮类.近年来诸多研究报道,该病原体对多西环素及阿奇霉素的耐药程度日趋严重,亦不断出现莫西沙星治疗失败的案例.本文对生殖支原体耐药位点突变情况及治疗研究进展进行了综述.