目的 探讨分泌型Frizzled相关蛋白2(sFRP-2)在宫颈癌及癌前病变组织中的表达及临床意义.方法 免疫组化SABC法检测51例宫颈鳞癌组织、63例宫颈上皮内瘤变组织和30例正常宫颈组织中sFRP-2蛋白的表达情况, 并分析宫颈鳞癌组织中sFRP-2蛋白表达与临床病理参数的关系.结果 sFRP-2的表达在宫颈上皮内瘤变组织和宫颈鳞癌组织中明显低于正常宫颈组织, 差异有统计学意义(P<0.05);宫颈上皮内瘤变Ⅲ级组低于低度病变组(Ⅰ级和Ⅱ级), 差异有统计学意义(P<0.05), 宫颈鳞癌组sFRP-2的表达低于低度病变组, 差异有统计学意义(P<0.05);宫颈鳞癌组sFRP-2的表达低于高度病变组(P<0.05);在宫颈鳞癌组中, sFRP-2的表达与年龄、肿瘤浸润深度、临床分期、淋巴结有无转移均无相关性(P>0.05),而在不同组织分化程度间表达差异有统计学意义(P<0.05).结论 经典Wnt信号通路的主要抑制因子sFRP-2蛋白的低表达与宫颈病变的发生、发展有关.%Objective To investigate the expression of sFRP-2 in patients who are suffered from cervical intraepithelial neoplasia and cervical carcinoma.Methods Detected sFRP-2 by immunohistochemistry (SABC)in fibroid tissue(51 cases), cervical intraepithelial neoplasia(63 cases) and cervicalsquanlous cell carcinoma(30 cases).Results The expression of sFRP-2 protein in cervical cancer tissues was significantly lower than that in cervical hyperplasia and normal cervical tissues, and their differences were statistically significant(Pall<0.05);in cervical squamous cell carcinoma group, there was no significant difference for sFRP2 in different age patientgroups, and there was no difference among different tumor size, node、and clinical stages. However, there was significant difference between different pathological grades(P<0.05).Conclusion The lower expression of sFRP-2 make an important role in the cervical lesion progress.
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