目的：探讨抗肿瘤药物所致严重不良反应的特点以及规律。方法回顾总结我院收治的抗肿瘤药物所致严重不良反应者共84例的临床资料，分析患者年龄、性别、药物分类、用药方法与严重不良反应的关系。结果51～60岁患者是发生抗肿瘤药物严重不良反应的高发阶段；服用其他类型（铂类、单克隆抗体、络氨酸激酶抑制剂等）药物的患者严重不良反应发生率最高；血液系统为不良反应主要涉及的系统；大部分严重不良反应患者经过临床救治均能获得不同程度的恢复。结论抗肿瘤药物所致严重不良反应与患者年龄、药物类型以及用药方法息息相关，严重者将会导致患者死亡，医护人员应该加强对肿瘤患者严重不良反应的监测，合理用药。%Objective To investigate the characteristics and regularity of the adverse drug reactions induced by anti tumor drugs. Methods The clinical data of 84 cases of serious adverse reactions caused by anti tumor drugs in our hospital were reviewed,the relationship between age,gender,drug classification, drug use and serious adverse reactions were analyzed. Results Patients with 51 ~ 60 years old were the high risk of adverse drug reactions,and the incidence of severe adverse reactions in patients taking other drugs(platinum,monoclonal antibodies,tyrosine kinase inhibitors,etc)was the highest,and the system was mainly involved in the patients with adverse reactions. Conclusion The serious adverse reactions caused by anti tumor drugs are closely related with age,drug classification and drug use,which wil result in the death of the patients. The medical staff should strengthen the monitoring of the serious adverse reactions in patients with cancer.
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