内分泌联合唑来膦酸治疗晚期前列腺癌临床对照研究

摘要

目的：探讨内分泌联合唑来膦酸治疗晚期前列腺癌的临床效果。方法选取我院自2011年3月～2014年3月间46例晚期前列腺癌患者作为研究对象，随机将其分成两组，对照组患者23例采用联合唑来膦酸治疗，观察组患者23例在对照组基础上增加内分泌治疗，对比两组患者的治疗效果。结果观察组患者治疗6月、12月的碱性磷酸酶（ALP）减少情况大于对照组，两组数据对比差异具有统计学意义，P<0.05。结论在治疗晚期前列腺癌时采用内分泌联合唑来膦酸治疗效果显著。%Objective To investigate clinical effects of endocrine therapy combined with zoledronic acid in advanced prostate cancer.Methods Since our hospital between March 2011 to March 2014,46 cases of advanced prostate cancer patients as research subjects,were randomly divided into two groups of 23 patients in the control group levelendocrine therapyacid treatment was observed in the control group,23 patients based on the use of zoledronic acid treatment group,compared to the therapeutic effect of the two groups of patients.Results Patients in the observation group in June,ALP 12 month reduction in cases was significantly greater than the control group,the difference was statistically significant data comparison,P< 0.05.Conclusion When the use of endocrine therapy for advanced prostate cancer combined zoledronic acid treatment significantly.