糖尿病酮症酸中毒早期诊断方法的对比研究

摘要

Objective To compare the serum ketone qualitative and quantitative detection of peripheral blood beta hydroxybutyrate and urine ketone qualitative detection in diabetic ketoacidosis(DKA)in the early diagnosis of difference.Methods Diabetic ketoacidosis(DKA group)53 cases,non ketotic diabetes(NDK group)50 cases,30 cases of healthy volunteers was as control group,serum ketone qualitative and peripheral blood of three groups of beta hydroxybutyric acid and quantitative urine ketone test results.Results Diabetic ketoacidosis(DKA group)serum ketone qualitative and peripheral blood beta hydroxybutyrate quantitative detection in diagnosis of diabetic ketoacidosis positive rate was 100%,significantly higher than the results of urine ketone test results(P>0.05). Two diagnosis rate has no obvious difference,the diagnosis rate was significantly higher than that of urine ketone. Non ketotic diabetes(NDK group)in the patients may have high ketonemia,ketonuria in healthy volunteers to detect the presence of false positive results.Conclusion Diabetic ketoacidosis in peripheral blood ketone(DKA)quantitative detection of early diagnosis has certain advantages,clinical and urine ketone testing combination of disease diagnosis more accurate and timely.%目的：比较血清酮体定性、末梢血β-羟丁酸定量检测及尿酮定性检测在糖尿病酮症酸中毒（DKA）早期诊断中的价值。方法糖尿病酮症酸中毒（DKA组）患者53例，非酮症糖尿病（NDK组）患者50例，健康志愿者30例作为对照组，比较三组血清酮体定性及末梢血β-羟丁酸定量及尿酮体检测结果。结果糖尿病酮症酸中毒（DKA组）血清酮体定性、末梢血β-羟丁酸定量检测在诊断糖尿病酮症酸中毒时阳性率均为100%，二者诊断率差异无统计学意义（P＞0.05），且高于尿酮体诊断率。非酮症糖尿病（NDK组）中患者可能存在高酮血症，健康志愿者中尿酮体检测存在假阳性结果。结论末梢血酮定量检测在糖尿病酮症酸中毒（DKA）早期诊断中具有一定优势，临床上与尿酮体检测相结合，对疾病诊断更及时、准确。