探讨早期糖皮质激素冲击疗法对视神经脊髓炎视功能恢复的影响

摘要

目的：探讨分析视神经脊髓炎使用早期糖皮质激素冲击疗法后视功能恢复情况。方法对我院42例视神经脊髓炎患者进行分析研究，共有患眼50只，分成对照组和观察组，均有21例。观察组使用甲泼尼龙，地塞米松注射，泼尼松片口服治疗；对照组使用地塞米松注射，泼尼松片口服治疗，对比临床治疗效果。结果经过治疗后，观察组的临床治疗有效率是80.77%，对照组是66.67%，结果差异存在统计学意义（P＜0.05）；观察组视网膜神经纤维层（RNFL）厚度高于对照组，结果差异存在统计学意义（P＜0.05）；观察组Barthel指数评分高于对照组（P＜0.05）。结论视神经脊髓炎使用早期糖皮质激素冲击疗法的效果突出，患者视力和日常生活能力有改善。%Objective To investigate and analysis the visual function recovery early use of methylprednisolone in neuro myelitis optica.Methods To analysis the 42 cases of neuro myelitis optica patients in our hospital. Both 50 eyes were divided into control group and observation group, 21 cases in earch group. The observation group using methylprednisolone, dexamethasone, prednisone; control group with dexamethasone injection, prednisone, compared the clinical treatment effect.ResultsAfter treatment, the clinical effective rate in the treatment group was 80.77%, the control group was 66.67%, there was a signiifcant difference between the results of the observation group (P < 0.05); retinal nerve ifber layer (RNFL) thickness is higher than the control group, there were signiifcant differences (P < 0.05); the observation group barthel score higher than the control group (P < 0.05). Conclusion The effect of glucocorticoid therapy in early stage of optic nerve myelitis is prominent, and the visual acuity and daily living ability of the patients have been improved signiifcantly.