血清降钙素原检验结果和急性心肌梗死患者炎症反应关系

摘要

Objective To explore the relationship between serum calcitonin original test results and inflammatory response in patients with acute myocardial infarction. Methods Selected in our hospital meet the diagnostic criteria of patients in 171 cases 2014-6~2015-03 admissions, through random sampling were divided into three groups: angiographically normal coronary artery group (control group), of angina pectoris group (SAP group), acute myocardial infarction group, the number of patients in each group for 54 cases, 57 cases, 60 cases; for in-depth analysis of patients in each group, in accordance with age are divided into two classes: 50 year old patient and less than or equal to 50 patients. All patients were treated with high-sensitivity C-reactive protein (hs CRP), serum calcitonin peptide (PCT) and coronary artery angiography and neutrophil cell percentage determination. Results Compared with SAP group and control group, the serum levels of calcitonin in AMI group were significantly increased, the difference was statistically significant (P<0.05). For all receive operating characteristic curve test were analyzed, the serum procalcitonin is an independent factor, harmful effects of AMI in SAP group and control group in serum procalcitonin and high-sensitivity C reactive protein is not related, high sensitivity C AMI group serum C-reactive protein and procalcitonin showed a relationship positive correlation; analysis of age statistics, in the SAP group compared with less than 50 years, high sensitive C reactive protein in the serum of patients with>50 showed an increasing trend, the data are different, with statistical significance (P<0.05), AMI group compared to less than 50 year old patient serum in the aged >50 patients showed calcitonin the rise, data are different, with statistical significance (P<0.05), in the control group, two age comparison of high sensitive C reactive protein, serum procalcitonin, no difference, no statistical significance (P>0.05), SAP group and AMI group in age Gender, disease and other aspects of no difference, not in line with statistical significance (P>0.05). Conclusion Serum calcitonin factor applied to the acute inflammatory response in patients with acute myocardial infarction and has widely application value, sensitive C-reactive protein, on 50 years and less than or equal to 50 years old in patients with serum calcitonin angiotensinogen is sensitive.%目的：探究血清降钙素原检验结果和急性心肌梗死患者炎症反应关系。方法文章选取了该院在2014年6月—2015年3月接诊的171例符合诊断标准的患者,通过随机抽样的方式分成3组：冠状动脉造影正常组(对照组)、性心绞痛组(SAP组)、急性心肌梗死组,每组患者人数为54例、57例、60例；各组患者依照年龄的不同分成两类：>50岁患者和≤50岁患者。所有患者均接受高敏C反应蛋白(hs-CRP )、血清降钙素原(PCT )等,冠状动脉造影检查与中性粒细胞百分比测定。结果对比SAP组、对照组,AMI组患者血清中的降钙素明显升高,差异有统计学意义（P<0.05)。对所有接受测试的患者的工作特征曲线分析得出,血清降钙素原是影响AMI独立危害因素,此外,SAP组和对照组血清中的降钙素原与高敏C反应蛋白没关联性,AMI组血清中高敏C反应蛋白和降钙素原表现出正相关的关系；对年龄统计分析,SAP组中相比≤50岁患者,>50岁患者血清中的高敏C反应蛋白呈现升高趋势,数据间,差异有统计学意义(P<0.05),AMI组相比≤50岁患者,>50岁患者体内的血清降钙素呈明显上升趋势,数据间,差异有统计学意义(P<0.05),在对照组中,两类年龄对比高敏C反应蛋白、血清降钙素原等,差异无统计学意义(P>0.05),SAP组、AMI组在年龄、性别和病症等方面,差异无统计学意义(P>0.05)。结论血清降钙素原应用到心肌梗死急性期炎症反应中,具有广泛的应用价值,相比超敏C反应蛋白,对>50岁和≤50岁患者体内出现的血清降钙素原反应敏感。