围术期应用布地奈德对食管癌患者开胸术后肺功能的保护作用及安全性研究

摘要

目的:观察围术期应用布地奈德对食管癌患者开胸术后肺功能的保护作用及安全性.方法:选择全麻下行开胸食管癌根治术患者80例,随机双盲分为A、B、C、D四组各20例.A组为小剂量布地奈德组,B组为大剂量布地奈德组,C组为对照组,D组为地塞米松组.观察四组患者围术期肺功能变化情况、VAS评分、不良反应发生情况.结果:A、B、D组患者术后肺功能优于C组(P均<0.05).A、B、D组患者术后VAS评分优于C组(P均<0.05).A组术后不良反应发生率低于B、D两组(P<0.05).结论:食管癌开胸手术围术期应用小剂量布地奈德安全有效.%objective:To observe the protective effect and safety of budesonide on lung function in patients with esophageal cancer after thoracotomy.Methods 80 cases of open radical resection of esophageal carcinoma under general anesthesia were selected,the patients were randomized double-blind divided into A,B,C,D four groups of 20 cases.Group A was low dose budesonide group,B group was high dose budesonide group,group C was control group,group D was dexamethasone group.The changes of pulmonary function,VAS score and adverse reactions were observed in four groups.Results A,B,D group of patients with postoperative lung function was better than C group (P all<0.05).A,B,D group of patients with postoperative VAS score was better than C group (P all<0.05).The incidence of adverse reactions in A group was lower than that in group B and group D (P<0.05).Conclusion low dose budesonide is effective and safe in the perioperative period of esophageal cancer.